[Triumf-seminars] TRIUMF Seminar today at 14:00

postmaster at admin.triumf.ca postmaster at admin.triumf.ca
Wed Dec 5 05:00:00 PST 2007

Date/Time: Wed 2007-12-05 at 14:00

Location:  Auditorium          

Speaker:   Ami Altman (Philips Medical Systems)

Title:     Enabling Molecular Imaging in the Main Imaging Modalities, Through New Generations of Radiation Detectors

Abstract: Some important advancements in radiation-detection technology, partially initiated by physicists in medical imaging, has accelerated evolution and paradigm change in the main medical-imaging modalities.  This has been accompanied by an intensive activity to prepare targeted radioactive tracers (PET & NM), as well as targeted contrast agents (CT & MR) aimed at specific pathologies.   “Molecular-Imaging” has been termed to describe all the new groups of clinical applications based on these new developments, although it doesn’t necessarily mean that single molecules are always measured.  Rather, specific molecular processes, or their results, are definitely imaged.  Some of the new detection technologies will be presented, as well as their clinical implications, along with some clinical results. 
The most important development in PET is the SiPM device (Si Photomultiplier).   Although this device had been already introduced before, it needed further development to meet PET requirements.  These new forms of SiPM enable much better coincidence timing than conventional PMs, as well as, better spatial resolution, without sacrificing energy resolution.   With this, a high quality TOF PET can become a reality as a commercial product, and a PET/MR hybrid can be considered, since SiPMs are not sensitive to magnetic fields.  Other forms of SiPM are capable of high-rate photon-counting, enabling Spectral-CT to be realized (at least in a moderate flux). 
Direct-conversion detectors (mainly based on CdZnTe and CdTe) propose alternative routes to apply photon-counting techniques enabling Spectral CT, as well as new types of gamma cameras.  Images from a CZT based Spectral CT prototype will be presented along with details on the detection technique itself.
Since the detection methods mentioned above are not ready yet for a full commercial product, they are used presently for preclinical research (small and medium-size animals).  On the other hand, to enable the application of Spectral CT as a commercial product in the short term, a unique detector configuration has been developed.  This detector is based on arrays of silicon p-i-n diodes reading a multi-layer scintillator stack (different scintillator materials), in a special geometrical configuration.   More than 2000 patients have been scanned with this system, demonstrating surprising results, some of which will be presented.

Stimulants available 15 minutes before the talk.


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