[Triumf-seminars] TRIUMF Special Seminar today at 15:30

[postmaster at admin.triumf.ca]

Date/Time: Tue 2008-02-26 at 15:30

Location:  Auditorium          

Speaker:   Esther Schirrmacher (McGill University)

Title:     F-18 labelling of peptides and proteins

Abstract: Many different strategies to label peptides and proteins have been described over the years. Acylation and photochemical conjugation as well as the use of alkylating agents, N-succinimidyl 4-[18F]fluorobenzoate, 2-[18F]fluoropropionic acid, p-[18F]fluorophenacyl bromide, 4-[18F]fluorobenzyl halides, 18F-labeled thiols, solid phase 18F-fluorinations and a hydrazone-formation by coupling 4-[18F]fluorobenzaldehyde to a hydrazinonicotinic acid (HYNIC) derivatized human serum albumine have been published. All the above mentioned methods using the conventional formation of a C-18F bond, although great improvements by all means, still suffer from various shortcomings such as multistep synthetic pathways, time consuming procedures and most notably the need for specially trained personnel to cope with all the complicated aspects of 18F-radiochemistry. Special focus will thus be laid on another approach, entirely build on the concept of isotopic 19F-18F exchange at a silicon-core. This concept was first published for peptide labeling, but has recently been transferred to an efficient and simple labeling approach for proteins.

Stimulants available 15 minutes before the talk. The speaker is a candidate for a professorship in the SFU chemistry department.

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