[Triumf-seminars] TRIUMF Colloquium, Thu 2018-02-15 at 14:00

[TRIUMF Seminars]

Date/Time: Thu 2018-02-15 at 14:00  

Location: Auditorium  

Speaker: Ekaterina Dadachova (U Saskatchewan)  

Title: Radioimmunotherapy with alpha-particles emitting radionuclides of  cancer and infections  

Abstract: The use of targeted therapy with alpha particles emitters in oncology is burgeoning worldwide. This is driven by the advantages of alpha emitters over beta emitters, including very specific targeting of the diseased cells due to the alpha particles' short 50-80 micron tissue range, and increased killing efficiency due to high linear energy transfer. This results in a controlled therapeutic modality with minimal normal tissue effects. Radioimmunotherapy (RIT) with alpha emitters does not depend on the oxygenation status of the tumor, and alpha therapy can break tumor resistance to chemotherapy, external beam radiation therapy, and even to beta radiation therapy. In our laboratory we are investigating novel antigens and antibodies for using alpha RIT to treat melanoma and pancreatic cancer. Several years ago we were the first to translate alpha RIT approach into the field of infectious diseases for treatment of opportunistic fungal infections, multidrug resistant bact
 erial infections and HIV. The latest results of our pre-clinical work will be described.