[Triumf-seminars] TRIUMF Colloquium today at 14:00

[TRIUMF Seminars]

Date/Time: Wed 2018-07-25 at 14:00

Location:  Auditorium          

Speaker:   Cathy Cutler (Brookhaven National Lab)

Title:     Isotope Production at Brookhaven

Abstract: As vectors have advanced in their size, shape and complexity, so has the need for longer-lived positron emitters.  It can take days for selective targeting of antibodies to reach maximum uptake in tumor tissue.  Brookhaven National Laboratory (BNL) is investigating high energy proton  production of longer lived positron emitters that can be made available via generators to hospitals for preclinical and clinical use.  The two we are focused on is Sc-44 (half-life 3.97 hr) that is produced via decay of Ti-44 (half-life of 60 yr) and As-72 (half-life = 26 hr) that is produced via the decay of Se-72 (half-life = 8 days).  In addition to the irradiation of the target to produce the parent isotopes by high energy proton irradiations, BNL is investigating optimized production and purification methods.  As well as generator systems that would enable these to be used similarly to Tc-99m and Ga-68 generators.  Scandium-44 has chemistry similar to many commonly used +3 radio metals and thus can use the common ligands.  However, As-72 has very different chemistry and we have been working in collaboration with researchers at the University of Missouri on developing unique ligands that can be used to attach As radio metals to peptides and antibodies for both diagnostic and therapeutic applications.  Results on these efforts will be presented.



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