[Triumf-seminars] TRIUMF Colloquium today at 11:00

[TRIUMF Seminars]

Date/Time: Thu 2023-09-07 at 11:00

Location:  NRC Conference Rm   

Speaker:   Rachel Codd (University of Sydney)

Title:     Expanding the structural diversity of radiometal chelators for nuclear medicine

Abstract: The set of bifunctional chelators used for targeted radiometal nuclear medicine is small. This can result in suboptimal matches between the chelator and metal ion for imaging and treatment. Designing general methods to widen the chemical space of chelators could expand the clinical benefit available from using known and emerging radioisotopes. Our group blends chemistry, microbiology, and molecular biology approaches to access new chelators with new properties. We have considered how bacteria biosynthesize selected natural product chelators, as necessary for their survival, and transferred these methods to a laboratory setting. We have generated high-denticity and water soluble chelators for zirconium(IV)-89, and used a metal-templating approach to allow the metal ion to self-select its own best chelator. Our most recent work re-casts combinatorial chemistry used in drug discovery to chelator discovery. This presentation will provide snapshots of these methodological advances in widening chemical space of chelators, which together with advances in radioisotope production and purification, offer potential to expand the clinical benefit available within the Radiometal Periodic Table.



Please note this lecture is in NRC Conference room due to auditorium renovation.  It is a short walk from TRIUMF. The conference is right at the entrance.


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General TRIUMF seminar information available at http://www.triumf.ca/home/upcoming-events/about-seminars-lectures