[Triumf-seminars] TRIUMF Seminar today at 14:00

[postmaster at admin.triumf.ca]

Date/Time: Thu 2010-03-25 at 14:00

Location:  Auditorium          

Speaker:   Matt Webster (General Electric Global Research)

Title:     Utilizing a molecular transporter to image oxidative stress in vivo

Abstract: The utilization of a glucose transporter to take up and retain a radiolabel in order to detect an increase in cellular metabolism defines the strategy of the prolific prototype PET imaging agent, 18F-fluoro-deoxyglucose.  Additionally, a number of promiscuous amino acid transporters are currently being evaluated and in some cases utilized as an additional mechanism to image increased cellular metabolism.  Here we will discuss a new strategy to utilize another molecular transporter to image cellular function.  However, rather than imaging an increase in metabolism, this transport system may allow in vivo detection a cellular response to oxidative stress.  Imaging oxidative stress in vivo could be significant for the diagnosis and monitoring of a wide range of pathological indications.  Potential uses may include cancer detection, staging or monitoring of response to therapy; stroke, myocardial infarction and organ transplant rejection monitoring or any condition that includes cellular oxidative stress.  Our data suggests certain molecular determinants that appear to be important for the development of a good PET imaging agent utilizing this transporter.   Preliminary in vivo studies suggest that such an agent would be suitable for PET imaging.

Stimulants available 15 minutes before the talk.

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