[Triumf-seminars] TRIUMF Colloquium today at 14:00

[TRIUMF Seminars]

Date/Time: Thu 2015-10-22 at 14:00

Location:  Auditorium          

Speaker:   David Robertson (U of Missouri)

Title:     Layered Nanoparticles for Targeted Alpha Generator Radiotherapy

Abstract: Targeted radiotherapies based on alpha emitters are a promising alternative to beta emitting radionuclides. Because of their much shorter range, targeted alpha-radiotherapy (TAT) agents have great potential for application to small, disseminated tumors and micro metastases and treatment of hematological malignancies consisting of individual, circulating neoplastic cells. A promising approach to TAT is the use of the in vivo alpha-generator radionuclides 223Ra (t1/2 = 11.4 d) and 225Ac (t1/2 = 10.0 d). In addition to their longer half-lives, these two isotopes have the potential of dramatically increasing the therapeutic efficacy of the endoradiotherapy as they each emit four alpha-particles in their decay chain. This principle has recently been exploited in the development of Xofigo(R), the first TAT agent approved for clinical use by the U.S. Food and Drug Administration.  Xofigo(R), formulated as 223RaCl2, is used for treatment of metastatic bone cancer in men with castration-resistant prostate cancer. Targeted therapy with 223Ra works in the case of bone cancer because radium, as a chemical analogue of calcium, efficiently targets bone. Further, the 223Ra decay daughters are either short lived or also have affinity for bone, limiting their movement into general circulation to damage non-target tissue.  In order to bring the benefits of TAT with 223Ra or 225Ac to other tumor types, a new delivery method must be devised. This talk will focus on our development of a multilayered nanoparticle-antibody conjugate that can deliver multiple alpha radiations from the in vivo alpha-generator 225Ac at biologically relevant receptor sites.





















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J. David Robertson is a professor in the Chemistry Department at the University of Missouri, and Associate Director for Research and Education at the University of Missouri Research Reactor.  Dave obtained his B.S. degree in chemistry from the University of Missouri at Columbia in 1982 and his Ph.D. in nuclear chemistry from the University of Maryland at College Park in 1986.  After 2 years of postdoctoral research at the Lawrence Berkeley Laboratory, Dr. Robertson joined the chemistry faculty at the University of Kentucky in 1989.  He moved to the University of Missouri in 2000. Dave received the University of Missouri William H. Byler Distinguished Professor award in 2006 and was named as a Fellow of the American Chemical Society in 2010.  He currently serves as the National Director for the American Chemical Society Summer Schools in Nuclear and Radiochemistry.


Stimulants available 15 minutes before the talk.

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